What was studied?
Agitation-stress experiments compared surfactant effects on liraglutide, with exploratory work on semaglutide and glucagon.
What did the researchers report?
Surfactants sometimes increased aggregation instead of preventing it. Responses differed with peptide oligomer behavior and surfactant interaction strength.
What are the limits?
An excipient useful for one biologic may destabilize another. The study does not establish a universally suitable additive or replace product-specific stability testing.
Original editorial summary by Sulan Peptide. Based on the source abstract; consult the full paper for methods, analyses, funding and disclosures.