What was studied?
The investigators studied ipamorelin in primary rat pituitary cells, rats and swine, with other growth-hormone secretagogues as comparators. Their experiments measured growth hormone and several other pituitary or adrenal hormones.
What did the researchers report?
Ipamorelin stimulated growth-hormone release. In the reported swine experiments, its ACTH and cortisol response differed from that of the comparator secretagogues and was closer to the response associated with GHRH stimulation.
What are the limits?
Selectivity in particular animal experiments is not proof of absence of adverse effects in humans. This study did not establish clinical benefits or long-term safety. Species, assay conditions and the exact peptide identity limit the transfer of these results to other settings.
Original editorial summary by Sulan Peptide. Based on the source abstract; consult the full paper for methods, analyses, funding and disclosures.